Perancangan Maskot “Planktoon Fingerboard” sebagai Upaya Meningkatkan Brand Loyalty

Planktoon known as Planktoon Fingerboard, is a company engaged in the field of life style product that has specifications field in fingerboard. Fingerboard is a skateboard's miniature that made in the same detail as the size of the original skateboard, but it has smaller size to make it more comfortable in play using the fingers. Planktoon founded in 2009, exactly 23 October 2009, from there began the management system created for branding fingerboard with pride. Planktoon brand name, logo and stationery set has been made yet before, but Planktoon has not had a mascot, just like brand competitors from Planktoon. Therefore in order to improve the image of Planktoon. Mascot hopefully can educate consumers and increase Planktoon's brand image. Designing qualitative method with interviews, observation, and existing studies to find a formula for the design concepts underlying the design of the mascot, the data analysis found a variety of unique and how branding brand with mascots that have not been known by the public, so consumers are not only given a new product continuously without any explanation interesting, with mascot be easier for consumers to understand about Planktoon. After analyzing the concepts found and a name for the mascot design Planktoon the "Smile", which means a character who has a cheerful soul, friendly, and the helper soul. The name of Planktoon's mascot is "Mr. Toon". The word is derived from the word Mr. and Toon word derived from Plank-toon to represent brand Planktoon

Transcriptome Modifications in Porcine Adipocytes via Toll-Like Receptors Activation

Adipocytes are the most important cell type in adipose tissue playing key roles in immunometabolism. We previously reported that nine members of the Toll-like receptor (TLR) family are expressed in an originally established porcine intramuscular pre-adipocyte (PPI) cell line. However, the ability of TLR ligands to modulate immunometabolic transcriptome modifications in porcine adipocytes has not been elucidated. Herein, we characterized the global transcriptome modifications in porcine intramuscular mature adipocytes (pMA), differentiated from PPI, following stimulation with Pam3csk4, Poly(I:C) or LPS which are ligands for TLR2, TLR3, and TLR4, respectively. Analysis of microarray data identified 530 (218 up, 312 down), 520 (245 up, 275 down), and 525 (239 up, 286 down) differentially expressed genes (DEGs) in pMA following the stimulation with Pam3csk4, Poly(I:C), and LPS, respectively. Gene ontology classification revealed that DEGs are involved in several biological processes including those belonging to immune response and lipid metabolism pathways. Functionally annotated genes were organized into two groups for downstream analysis: immune response related genes (cytokines, chemokines, complement factors, adhesion molecules, and signal transduction), and genes involved with metabolic and endocrine functions (hormones and receptors, growth factors, and lipid biosynthesis). Differential expression analysis revealed that EGR1, NOTCH1, NOS2, TNFAIP3, TRAF3IP1, INSR, CXCR4, PPARA, MAPK10, and C3 are the top 10 commonly altered genes of TLRs induced transcriptional modification of pMA. However, the protein-protein interaction network of DEGs identified EPOR, C3, STAR, CCL2, and SAA2 as the major hub genes, which were also exhibited higher centrality estimates in the Gene-Transcription factor interaction network. Our results provide new insights of transcriptome modifications associated with TLRs activation in porcine adipocytes and identified key regulatory genes that could be used as biomarkers for the evaluation of treatments having immunomodularoty and/or metabolic functional beneficial effects in porcine adipocytes.Fil: Igata, Manami. Tohoku University; JapónFil: Islam, M. Aminul. Tohoku University; Japón. Bangladesh Agricultural University; BangladeshFil: Tada, Asuka. Tohoku University; JapónFil: Takagi, Michihiro. Tohoku University; JapónFil: Humayun Kober, AKM. Tohoku University; Japón. Chittagong Veterinary and Animal Sciences University; BangladeshFil: Albarracín, Leonardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; Japón. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Ciencias de la Computación; ArgentinaFil: Aso, Hisashi. Tohoku University; JapónFil: Ikeda-Ohtsubo, Wakako. Tohoku University; JapónFil: Miyazawa, Kenji. Takanashi Milk Products Co.; JapónFil: Yoda, Kazutoyo. Takanashi Milk Products Co.; JapónFil: He, Fang. Takanashi Milk Products Co.; JapónFil: Takahashi, Hideki. Tohoku University; JapónFil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; JapónFil: Kitazawa, Haruki. Tohoku University; Japó

Bone morphological effects on post-implantation remodeling of maxillary anterior buccal bone: A clinical and biomechanical study

This is the final version of the article. Available from Elsevier via the DOI in this record.Purpose This study combines clinical investigation with finite element (FE) analysis to explore the effects of buccal bone thickness (BBT) on the morphological changes of buccal bone induced by the loaded implant. Methods One specific patient who had undergone an implant treatment in the anterior maxilla and experienced the buccal bone resorption on the implant was studied. Morphological changes of the bone were measured through a series of cone-beam computed tomography (CT) scans. A three-dimensional heterogeneous nonlinear FE model was constructed based on the CT images of this patient, and the in-vivo BBT changes are correlated to the FE in-silico mechanobiological stimuli; namely, von Mises equivalent stress, equivalent strain, and strain energy density. The anterior incisory bone region of this model was then varied systematically to simulate five different BBTs (0.5, 1.0, 1.5, 2.0, and 2.5 mm), and the optimal BBT was inversely determined to minimize the risk of resorption. Results Significant changes in BBTs were observed clinically after 6 month loading on the implant. The pattern of bone resorption fell into a strong correlation with the distribution of mechanobiological stimuli onsite. The initial BBT appeared to play a critical role in distributing mechanobiological stimuli, thereby determining subsequent variation in BBT. A minimum initial thickness of 1.5 mm might be suggested to reduce bone resorption. Conclusions This study revealed that the initial BBT can significantly affect mechanobiological responses, which consequentially determines the bone remodeling process. A sufficient initial BBT is considered essential to assure a long-term stability of implant treatment.This study was supported by Australian Research Council (ARC) through Discovery and Future Fellowship Schemes (DP1095140 and FT120100947), and for Scientific Research (C) (15K11147) from the Ministry of Education, Culture, Sports, Science and Technology of Japan

The Effect of Aerobic and Anaerobic Physical Training on the Absorptive Cells, Absorption of Carbohydrate and Protein in Small Intestine

The purpose of this study is to investigate the morphofunctional response of a total number of absorptive cells, and carbohydrate and protein absorption capability in the small intestine of Rattus norvegicus strain Wistar (RNSW) that has been subjected to aerobic and anaerobic physical training based on the morphofunctional physiological paradigm. This study was based on the separate sample pretest-posttest control group design, using a t-test, and multivariate SPSS ten program, with five percent level of significance. The sample consisted of one hundred and twenty, male RNSW, with average age of five months, and body weight of 246-278 grams. They were divided into twelve groups at random, i.e. four pretest groups, two control groups, and six treated groups where different diets were given thirty minutes before undergoing posttest. The experimental animals underwent four weeks physical training (twelve times), three groups were given aerobic physical training by swimming with a burden of three percent fasting body weight, the others three groups received anaerobic physical training by swimming with a burden of nine percent fasting body weight. The experiment was conducted at night, between 7.30 PM to 10.30 PM, in a water with a temperature of    28°C to 30°C. Result of the study revealed: (1) Aerobic and anaerobic physical training, increased the number of absorptive cells (t = -73,281, p = 0,000), and increased the absorptive capacity of carbohydrate and protein (Hotelling's Trace = 0,244, p = 0,000). (2) There was a difference in the increased absorptive capacity of carbohydrate and protein among groups (Hotelling's Trace = 0,404a, p = 0,000). Aerobic physical training had less influence than anaerobic physical training on the increased number of absorptive cells, and the absorptive capacity of carbohydrate and protein in the small intestine. In conclusion: (1) Aerobic physical training of swimming with a burden of three percent fasting body weight, and anaerobic physical training of swimming with a burden nine percent fasting body weight correlate with the increase the number of absorptive cells, and carbohydrate and protein absorptive capacity of the small intestine. (2) Anaerobic physical training of swimming with a burden nine percent fasting body weight has better correlation than aerobic physical training of swimming with a burden of three percent fasting body weight with the increased number of absorptive cells, and the absorptive capacity of carbohydrate and protein in the small intestine

The Effect of Aerobic and Anaerobic Physical Training on the Absorptive Cells, Absorption of Carbohydrate and Protein in Small Intestine

The purpose of this study is to investigate the morphofunctional response of a total number of absorptive cells, and carbohydrate and protein absorption capability in the small intestine of Rattus norvegicus strain Wistar (RNSW) that has been subjected to aerobic and anaerobic physical training based on the morphofunctional physiological paradigm. This study was based on the separate sample pretest-posttest control group design, using a t-test, and multivariate SPSS ten program, with five percent level of significance. The sample consisted of one hundred and twenty, male RNSW, with average age of five months, and body weight of 246-278 grams. They were divided into twelve groups at random, i.e. four pretest groups, two control groups, and six treated groups where different diets were given thirty minutes before undergoing posttest. The experimental animals underwent four weeks physical training (twelve times), three groups were given aerobic physical training by swimming with a burden of three percent fasting body weight, the others three groups received anaerobic physical training by swimming with a burden of nine percent fasting body weight. The experiment was conducted at night, between 7.30 PM to 10.30 PM, in a water with a temperature of    28°C to 30°C. Result of the study revealed: (1) Aerobic and anaerobic physical training, increased the number of absorptive cells (t = -73,281, p = 0,000), and increased the absorptive capacity of carbohydrate and protein (Hotelling\u27s Trace = 0,244, p = 0,000). (2) There was a difference in the increased absorptive capacity of carbohydrate and protein among groups (Hotelling\u27s Trace = 0,404a, p = 0,000). Aerobic physical training had less influence than anaerobic physical training on the increased number of absorptive cells, and the absorptive capacity of carbohydrate and protein in the small intestine. In conclusion: (1) Aerobic physical training of swimming with a burden of three percent fasting body weight, and anaerobic physical training of swimming with a burden nine percent fasting body weight correlate with the increase the number of absorptive cells, and carbohydrate and protein absorptive capacity of the small intestine. (2) Anaerobic physical training of swimming with a burden nine percent fasting body weight has better correlation than aerobic physical training of swimming with a burden of three percent fasting body weight with the increased number of absorptive cells, and the absorptive capacity of carbohydrate and protein in the small intestine

AN EXPERIMENTAL AND MODELING STUDY OF ELECTROOSMOTIC BULK AND NEAR-WALL FLOWS IN TWO-DIMENSIONAL MICRO-AND NANOCHANNELS

ABSTRACT Electrokinetically driven flow of electrolyte solutions through micro-and nanochannels is of interest in microelectromechanical systems (MEMS) and nanotechnology applications. In this work, fully developed and steady electroosmotic flow (EOF) of dilute sodium tetraborate and sodium chloride aqueous solutions in a rectangular channel where the channel height h is comparable to its width W is examined. EOF is also studied under conditions of electric double layer (EDL) overlap, or λ/h ~ O(1), where λ is the Debye thickness, for very dilute solutions. The initial experimental data and model results are in very good agreement for dilute sodium tetraborate solutions. The experimental work uses the new nano-particle image velocimetry (nPIV) technique. Evanescent waves from the total internal reflection of light with a wavelength of 488 nm at a refractive index interface is used to illuminate 100 nm neutrally buoyant fluorescent particles in the near-wall region of the flow. The images of these tracer particles over time are processed to obtain the two components of the velocity field parallel to the wall in fully developed EOF of sodium tetraborate at concentrations up to 2 mM in fused quartz rectangular channels with height h up to 10 microns. The spatial resolution of these velocity field data along the dimension normal to the wall is about 100 nm, and the data are obtained within a distance of approximately 100 nm of the wall based upon the 1/e intensity point, or penetration depth. A set of equations modeling EOF in a long channel are solved where h/L << 1, and L is the lengthscale along the flow direction. Unlike most previous models, this work does not use the Debye-Huckel approximation, nor does it assume symmetric boundary conditions. For the case where λ/h << 1, analytical solutions for the velocity, potential and mole fractions are obtained using an asymptotic perturbation approach